Synthesis, Characterization and In vitro evaluation of antibacterial and antifungal activities of New Schiff Base and Its Metal Complexes

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Salim Madani Kamel Mokhnache Azeddine Rouane Noureddine Charef


A new potentially pentadentate Schiff base ligand L has been prepared via the condensation of diethylenetriamine and 2’-hydroxyacetophenone in the molar ratio of 1:2 in absolute ethanol and characterized by elemental analyses and UV, IR spectroscopy. Mn(II), Ni(II), Co(II), Cu(II),Fe(III),Mg(II),Cd(II) and Zn(II) complexes were prepared by reaction of L,dissolved in ethanol, with an appropriate metal salt, have been characterized by UV and IR spectroscopy. Furthermore, the synthesized compounds were screened for antibacterial and antifungal activities. Almost all of these compounds showed moderate to excellent antimicrobial activity against four gram negative bacteria (Escherichia coli, Salmonella typhimurium, Acinetobacter baumannii and Citrobacter freundii), two gram positive bacteria (Enterococcus faecalis andLysteria monocytogenes), pathogenic fungal strains (Candida albicans, Aspergillus niger, Aspergillus flavus and fusarium oxysporum). The activities were confirmed by Activity Index (AI). Activity Index values were found to be higher for Cd(II)  followed by Co(II) and the other compounds. The Minimum Inhibitory Concentration (MIC) L and its metal complexes were also determined.

Keywords: Schiff base; Complexes;  Synthesis; Bacteria; Fungus.

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Madani, S.; Mokhnache, K.; Rouane, A.; Charef, N. Synthesis, Characterization and In Vitro Evaluation of Antibacterial and Antifungal Activities of New Schiff Base and Its Metal Complexes. Materials and Biomaterials Science 2019, 3, 001-009.
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