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Sodium Carboxymethylcellulose (NaCMC) was subjected to an acidification reaction by hydrochloric acid. Characterization and identification of acidified carboxymethylcellulose (HCMC) was made by Fourier transformed Infrared spectroscopy (FT-IR), Elemental analysis (XRF) and Thermal analysis (TGA - DSC). The opacity measurement shows a marked difference in powders structure. The blood-clotting tests demonstrate that HCMC is more hemostatic than NaCMC. Mucoadhesion exhibits a pronounced increase in adhesion times of HCMC contrary to NaCMC on the gastric and intestinal mucosa. Besides, biodegradability is established.
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